Police are investigating a road traffic collision which occurred on the A7 between Carlisle and Longtown.
Emergency services were called at 4:04pm yesterday, Tuesday 9 October.
A white VW Polo travelling towards Longtown was involved in a near head-on collision with a white Land Rover travelling in the opposite direction near to Westlinton.
A Cumbria Police spokesman said: “Despite the efforts of doctors and paramedics, including air ambulance staff, the driver of the Polo died at the scene, he is believed to be a 41-year-old man from the Hampshire area, although he has not yet been formally identified.
“The male and female occupants of the Land Rover needed to be cut free from their vehicle by Cumbria Fire and Rescue Service. They were taken to the Cumberland Infirmary although their injuries are believed to be minor.”
A spokesman for Cumbria Fire and Rescue Service said: “At 4:14pm two appliances from Longtown and Carlisle East were mobilised to a serious road traffic collision on the A7 Westlinton, Carlisle involving two vehicles.
“Crews released three casualties using hydraulic cutting equipment and they were passed to the care of the ambulance service.
“Crews were in attendance approximately 90 minutes.”
The road was closed for six hours to allow for the scene to be examined and the vehicles to be recovered.
Any witnesses are asked to contact Cumbria Police on 101 quoting log 151 or 9th October.