At about 6.30pm on Tuesday police received a report of a two vehicle collision on the A69 near to Haydon Bridge.
It was reported that a blue Ford Focus estate was travelling westbound on the A69 when it has collided with a blue Hyundai I30 travelling in the opposite direction.
Emergency services attended the scene but sadly a woman, who was the front seat passenger in the Ford Focus, was pronounced dead at the scene.
A 21-year-old female rear seat passenger in the Ford Focus was also taken to hospital with serious but non-life threatening injuries.
The 62-year-old driver of the Hyundai was also taken to hospital for treatment but she is not believed to have suffered any serious injuries.
Enquiries into the circumstances around the collision are ongoing but the 31-year-old man who was driving the Ford Focus has been arrested on suspicion of causing death by dangerous driving.
He remains in police custody at this time and police are now appealing for any witnesses to the collision to get in touch.
Sergeant Craig Bartle, of Northumbria Police’s Motor Patrols Department, said: “This was a multi-vehicle collision that has resulted in a number of injuries and sadly a woman has lost her life.
“We are still carrying out enquiries this morning to formally identify the victim and inform her next of kin.
“An investigation to establish exactly what has happened will continue but we have arrested a man on suspicion of dangerous driving and he remains in custody.
“We need to speak to anyone who witnessed the collision or anyone who saw the Ford Focus in the area earlier that evening, is asked to call police.
“The vehicle is believed to have been in Newcastle earlier in the evening before it travelled west on the A69.
“We are also particularly keen to speak to anyone who may have dashcam footage of the incident.”
The A69 was closed for more than seven hours so officers could carry out their investigations but it has since been re-opened.
Anyone who witnessed the collision, or has information that may assist police, should call officers on 101 quoting log 873 20/08/19.
You can also report information online at the Northumbria Police website or email the investigating officer on [email protected].